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The gut microbiota links dietary polyphenols with management of psychiatric mood disorders
This 2019 review by Westfall and Pasinetti explored several potential therapeutic mechanisms in which dietary polyphenols are able to establish cognitive resilience in neuropsychiatric disorders. It also looked at how synbiotics (combination of probiotics and dietary polyphenols) may provide a novel therapeutic strategy for depression. The authors state that the multifactorial pathophysiology of depression requires a broad acting strategy, as gut-brain-axis signaling may play a crucial role in promoting resilience to several stress-induced changes. Furthermore, the interaction of the gut microbiota with dietary polyphenols can synergistically alleviate the biological signatures of depression. The phenolic metabolites of dietary polyphenols are known to have multiple beneficial properties and therapeutic efficacy against depression, while symbiotics have the potential to lessen neuroinflammation by modulating a number of factors — such as oxidative stress and serotonin metabolism. Effectively, they are capable of simultaneously targeting several major pathological risk factors of depression. Overall, synbiotics may act as a novel therapeutic paradigm for neuropsychiatric disorders. Further understanding of the fundamental mechanisms of gut-brain-axis signaling will allow greater utilization of the gut microbiota as a therapeutic tool. [NPID: psychiatric disorders, polyphenols, probiotics, synbiotics, depression, gut-brain axis, neuroinflammation, inflammation, oxidative stress, serotonin, microbiome, gut microbiota]
Year: 2019
