Role of oxidative stress and antioxidants in autism

This 2020 study explains autism spectrum disorder as a group of neurodevelopmental disorders with limited indication of its cause, which is diagnosed based on behavioral observations. Oxidative stress in autism has been investigated since it has been previously linked with increased levels of oxidative stress as well as lower antioxidant capacity. Several studies have suggested changes in the activities of antioxidant enzymes (such as superoxide dismutase, glutathione peroxidase, and catalase) in autism. Glutathione levels, homocysteine/methionine metabolism, increased inflammation, excitotoxicity, and mitochondrial and immune dysfunction have all been linked with autism. Furthermore, environmental, and genetic risk factors may contribute to enhanced susceptibility to oxidative stress in autism. These studies collectively imply that oxidative stress may have a role in the development of autism (with regards to pathogenesis and clinical symptoms). Scientists are trying to find ways to regulate the abnormal metabolite levels in the interconnected transmethylation and transsulfuration pathways observed in autism. This approach, and antioxidant supplementation have been associated with decreased autistic behaviors and severity. This paper provides a conceptual framework on oxidative stress and antioxidants utility. [NPID: autism, autism spectrum disorder, ASD, oxidative stress, behavior, antioxidants, neurodevelopmental disorders]

Year: 2020

Reference: Manivasagam, T., Arunadevi, S., Essa, M. M., SaravanaBabu, C., Borah, A., Thenmozhi, A. J., & Qoronfleh, M. W. (2020). Role of Oxidative Stress and Antioxidants in Autism. Advances in neurobiology, 24, 193–206. https://doi.org/10.1007/978-3-030-30402-7_7

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