Rationale for dietary antioxidant treatment of ADHD

This 2018 review states that stimulant medication use in children with ADHD (Attention-Deficit Hyperactivity Disorder) may have several limitations. Here, the authors showcase the research supporting the use of dietary antioxidant treatment in ADHD. This review describes the altered immune system in those with ADHD, how oxidative stress is regulated in this disorder, and explains epigenetic governance of gene expression. The development of chronic inflammation and oxidative stress can lead to ADHD symptoms. As an example, signs of ADHD can arise because of chronic T-cell-mediated neuroinflammation, neuronal oxidative damage and loss of normal cerebral functions. Therefore, modulating immune system activity and stabilizing the balance between oxidants and antioxidants using nutritional approaches may be useful in ADHD management. The use of natural antioxidants against oxidative conditions is an emerging field in the treatment of neurodegenerative diseases. For instance, dietary polyphenols may have a potential role in ADHD therapy since these have antioxidant capacities and can influence the immune system. Hopefully this review triggers further research and development of dietary antioxidant treatment in ADHD. [NPID: ADHD, attention deficit hyperactivity disorder, inflammation, oxidation, oxidative, stress, immune system, immunity, antioxidants, polyphenols, diet, nutrition]

Year: 2018

Reference: Verlaet, A., Maasakkers, C. M., Hermans, N., & Savelkoul, H. (2018). Rationale for dietary antioxidant treatment of ADHD. Nutrients, 10(4), 405.

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