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Polyunsaturated fatty acids: any role in rheumatoid arthritis?
This 2017 review looks at the potential use of polyunsaturated fatty acids (some of which [n-3s] have anti-inflammatory and pro-resolving properties) in rheumatoid arthritis (RA), a chronic inflammatory arthritis in which many inflammatory pathways contribute to joint and systemic inflammation, disease activity, and structural damage. The reviewers reported that data from animal models suggests supplementation with n-3 polyunsaturated fatty acids (n-3 PUFAs), which is found to be low in Western diets, may be an interesting perspective in future research as much in prevention as in treating RA. Human studies have implicated a diet high in n-3 PUFAs with a protective role for incident RA in subjects at risk. Supplementation with n-3 PUFAs could represent a promising therapeutic option to better control many features of RA as it could improve pain symptoms, the tender joint count, duration of morning stiffness and frequency of NSAID assumption. [NPID: pain, polyunsaturated fatty acids, anti-inflammatory, inflammation, arthritis, omega-3s, NSAIDs]
Year: 2017
