Polycystic ovary syndrome: New and promising treatment methods

Genetic, hormonal, and epigenetic factors all have a role in the multifactorial endocrine condition known as polycystic ovarian syndrome (PCOS). Affecting 10–13% of women globally, Polycystic ovary syndrome (PCOS) is linked to serious health issues, including infertility, dermatological symptoms such as hirsutism and acne, cardiovascular diseases, metabolic dysfunction, and psychological conditions. Although several hypotheses explain how illness develops, a multimodal approach is frequently necessary for effective therapy. According to clinical guidelines from the Russian Ministry of Health, lifestyle modification is the foundation of PCOS therapy. This review by Gasieva et al. (2024) examined about 60 studies from databases including PubMed, Nature Reviews, Oxford Academic, Clinical Nutrition, EJOG, Science Direct, and MDPI to evaluate nutritional strategies for Polycystic ovary syndrome (PCOS) treatment. Diets such as the Mediterranean, DASH, ketogenic, and low-carbohydrate plans showed the most promise. Supplementation with vitamins D and E, folic acid, calcium, and both probiotics and prebiotics is also recommended. Inositol and GLP-1 receptor agonists are emerging as promising treatments. In women with PCOS, dietary treatments have generally demonstrated significant benefits on metabolic markers and body composition. The key message is that PCOS management should be personalized and not rely solely on medications, considering that each woman’s unique needs are essential for effective care. [NPID: SLEEP, diet therapy, inositol, vitamin D, vitamin E]

Year: 2024

Reference: Gasieva, D. M., Sheremetyeva, E. V., Kalashnikova, M. F., Dzgoeva, F. Kh., & Alborova, E. T. (2024). Polycystic ovary syndrome: New and promising treatment methods. Problems of Endocrinology, 70(4), 103–113. https://doi.org/10.14341/probl13400

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