Phytochemicals in the treatment of Alzheimer’s disease: A systematic review

Due to the emerging evidence that plant-based biologically active compounds may slow down the onset and progression of Alzheimer’s disease (AD), D’Onofrio et al. (2017) conducted a systematic review examining the current literature on phytochemicals’ potential use in the management of Alzheimer’s disease. The review included articles that assessed cognitive, functional and clinical status using the suitable measures, and had participants aged 60 and above, with AD diagnosed according to the criteria of National Institute on Aging-Alzheimer’s Association (NIAAA). In total, ninety-seven articles were included. It appeared that numerous phytochemicals slow down the onset of AD, delay disease progression, and lead to recovery. Despite these positive signs, it is highlighted that more data is required on these phytochemicals and its molecular targets in order to ensure safety if these compounds are to be used to treat Alzheimer’s. [NPID: Alzheimer’s, cognition, herbs]

Year: 2017

Reference: D'Onofrio, G., Sancarlo, D., Ruan, Q., Yu, Z., Panza, F., Daniele, A., Greco, A., & Seripa, D. (2017). Phytochemicals in the Treatment of Alzheimer's Disease: A Systematic Review. Current drug targets, 18(13), 1487–1498. https://doi.org/10.2174/1389450117666161102121553