Microbiome, inflammation, epigenetic alterations, and mental diseases

This 2021 animal study was designed to test the effects of high-sucrose diets on mice lacking an enzyme called glyoxalase-1 (GLO1). The results demonstrated that a high-sucrose diet during adolescence induced psychosis-related behavioral factors such as hyperactivity and poor working memory. Following the intake of the high-sucrose diet, the researchers observed impairments in microcapillaries and […]

Research has been highly focused on the complex interactions that exist between the gut, the gut microbiota, and the central nervous system, thus associating the microbiome with disease pathogenesis, including that involving the central nervous system (CNS). Golofast and Vales (2020) therefore hypothesized that the gut microbiota may be linked with specific important stages in […]