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Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals
Although the gut microbiome influences host metabolism and is shaped by diet, these links may be unique to everyone, according to this 2021 study. Dr. Asnicar et al. sequenced the genes of 1203 gut microbiomes obtained from the participants of the Personalized Responses to Dietary Composition Trial (PREDICT 1) study. The subjects’ dietary information was retrieved, as well as their post-meal cardiometabolic blood marker measurements. Several strong associations were identified between microbes and specific nutrients, foods, food groups and general dietary indices. These links were often driven by the presence and diversity of healthy and plant-based foods. The microbial biomarkers of obesity were found to agree with circulating blood metabolites (indicators of cardiovascular disease risk). Some blood metabolites such as Prevotella copri and Blastocystis spp. indicated favorable post-meal glucose metabolism. But overall, microbiome composition could be used to predict a large panel of cardiometabolic blood markers (glucose, lipids, and inflammation). The microbial species associated with healthy dietary habits overlapped with those linked with favourable cardiometabolic and post-meal markers, indicating that these individuals could be ranked according to their generalizable health levels even without the presence of clinically manifest diseases.
[NPID: microbiome, microbes, gut, gut health, metabolites, genetics, obesity, gut microbiome]
Year: 2021
