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The detrimental impact of ultra-processed foods on the human gut microbiome and gut barrier
How ultra-processed foods (UPFs) influence the gut microbiome and gut barrier
Although ultra-processed foods (UPFs) have taken center stage in contemporary diets, there is growing worry about their impact on gut health. This review by Rondinella et al. (2025) explores how UPFs influence the gut microbiome and gut barrier, focusing on gut dysbiosis and increased intestinal permeability. UPFs are often poor in fiber and rich in synthetic chemicals and emulsifiers, which results in a proliferation of pro-inflammatory bacteria, a decrease in beneficial bacteria like Akkermansia muciniphila and Faecalibacterium prausnitzii, and a reduction in microbial diversity. Type 2 diabetes, metabolic syndrome, irritable bowel syndrome, and colon cancer are all associated with chronic inflammation, which is a result of these microbial imbalances. UPFs may also interfere with the gut-brain axis, which might affect mental and cognitive health. Adjusting dietary habits by incorporating fiber-rich foods, fermented products, and probiotics may help counteract the negative effects of UPFs. Furthermore, stricter regulations and clearer food labeling are necessary to reduce UPF consumption. Further research is essential to better understand the mechanisms linking UPFs to gut microbiome disturbances and systemic diseases, aiding in the development of evidence-based nutritional guidelines. [NPID: Ultra-processed foods, UPFs, gut microbiome, gut barrier]
Year: 2025
