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Gut microbiota and inflammatory factor characteristics in major depressive disorder patients with anorexia
In this study by Guo et al. (2024), the authors examined the gut microbiota and inflammatory variables in anorexic major depressive disorder (MDD) patients and the connections between HAMD scores, anorexia, inflammatory factors, and gut microbiota. The authors recruited 46 individuals with major depressive disorder and an equal number of healthy controls. Among the MDD patients, 20 had no anorexia (MDA0 group), and 26 had anorexia (MDA1 group). The Hamilton Depression Scale-24 (HAMD-24) was used to assess depression status, and 16S ribosomal RNA (16S rRNA) sequencing was employed to analyze gut microbiota composition. CRP and other inflammatory indicators were measured using the enzyme-linked immunosorbent assay (ELISA). The association between inflammatory markers, HAMD scores, anorexia, and gut microbiota was examined using Spearman’s correlation analysis. Analysis of the results revealed that 1) CRP levels were significantly higher in both MDD patients without anorexia and MDD patients with anorexia groups than healthy controls . 2) The MDD patients with anorexia group had lower Simpson and Pielou indices than controls, according to an analysis of α-diversity (i.e., the richness of microbiome species in the sample). 3) β-diversity analysis indicated differences in microbial community composition between MDD patients without anorexia, MDD patients with anorexia, and healthy controls. 4) A correlation study revealed that microbiota species Faecalibacterium, Bacteroides, Roseburia, and Parabacteroides had negative correlations with anorexia, HAMD scores, and CRP levels, but Blautia had positive correlations with all of these variables. This study demonstrated that MDD patients with anorexia exhibited distinct gut microbiota profiles and higher CRP levels compared to healthy controls. Blautia abundance was associated with anorexia, HAMD scores, and CRP levels, suggesting a potential link between gut microbiota, inflammation, MDD, and anorexia. [NPID: Major depressive disorder, anorexia, gut microbiota, inflammatory factors]
Year: 2024
