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Gut microbial dysbiosis in indian children with autism spectrum disorders
Although the cause of autism spectrum disorder (ASD) has not yet been confirmed, this 2018 article highlights that a disturbance of the gut-brain axis (communication that exists between the gut, microbiota, and brain) may be an important factor that contributes to autism. In this study, the fecal microbiota of 30 children with ASD were compared with that of 24 healthy children using next-generation gene sequencing. All participants were recruited from India. The autistic kids were also assessed on several markers associated with ASD such as the INCLEN Diagnostic Tool for Autism Spectrum Disorder (INDT-ASD) and the Indian Scale for Assessment of Autism (ISAA) tool. There was a notable imbalance in microbiota communities in the gut of autistic children, with higher abundances of families Lactobacillaceae, Bifidobacteraceae, and Veillonellaceae, compared to typically developing children. The dominant family in the gut microbiome of healthy children was Prevotellaceae. A comparative meta-analysis with another American dataset consisting of 20 ASD and 20 healthy control subjects (children) of similar age revealed a significantly high abundance of genus Lactobacillus in ASD children among both populations. In conclusion, microbial dysbiosis (imbalance in the microbial community) was evident in the gut microbiome of ASD children, which was associated with a high abundance of the Lactobacillus species. [NPID: gut microbiota, gut microbiome, gut bacteria, GI, gastrointestinal, autism, ASD, autism spectrum disorder, India, Indian, dysbiosis, autistic, children]
Year: 2018
