Gut-brain axis biochemical signaling from the gastrointestinal tract to the central nervous system: Gut dysbiosis and altered brain function

Here is a 2018 systematic review analyzing peer review articles on the relationship between human brain function and the gut-brain axis (a critical bidirectional link and communication between the brain and the gut). Arneth (2018) found that the gut-brain axis links various intestinal functions to brain centres through a wide selection of processes and pathways, such as endocrine signalling and immune system activation. Other findings included the bidirectional communication between different systems in the gut-brain axis were driven by the vagus nerve, and these signals are transmitted from the luminal environment to the central nervous system in humans. The researcher believes it is paramount to fully understand this gut-brain axis since this communication can influence brain function and trigger several psychiatric conditions for instance, such as schizophrenia and depression. [NPID: microbiome, MGBA, gut-brain axis, gut microbiome, brain function, vagus nerve, schizophrenia, depression]

Year: 2018

Reference: Arneth B. M. (2018). Gut-brain axis biochemical signalling from the gastrointestinal tract to the central nervous system: gut dysbiosis and altered brain function. Postgraduate medical journal, 94(1114), 446–452. https://doi.org/10.1136/postgradmedj-2017-135424