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Exploring the effects of a Mediterranean Diet and weight loss on the gut microbiome and cognitive performance in older, African American obese adults: A post hoc analysis
Mediterranean diet’s effects: Compared to non-Hispanic Whites, the African American population has a greater frequency of Alzheimer’s dementia (AD). Intentional weight loss (IWL) and the Mediterranean diet’s effects on the gut flora may change AD risk. To ascertain whether taking part in an 8-month Med Diet lifestyle intervention with or without IWL (n = 35) was associated with changes in gut microbiota abundance, structure, and function and whether these changes were connected to changes in cognitive performance, a post hoc analysis of the Building Research in Diet and Cognition (BRIDGE) trial was conducted by McLeod et al. (2023). The findings demonstrated a substantial increase in family and genus alpha diversity across both groups. There were no other noteworthy within- or between-group microbiological changes over time, though. Additionally, a decrease in alpha diversity at the phylum level only was strongly correlated with an increase in Med Diet adherence. After adjusting for Med Diet adherence, the connection between increasing alpha diversity and worsening cognitive function was decreased. In conclusion, the authors comment that gut microbiota was not significantly changed by an 8-month Med Diet lifestyle intervention, either with or without IWL. [NPID: Gut microbiota, cognition, Mediterranean diet, African Americans, Alzheimer’s dementia]
Year: 2023
