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Evaluation of some trace elements and vitamins in Major Depressive Disorder patients: A case-control study
This 2019 study recruited 60 patients with MDD and 60 individuals for control, matched by age and gender, and investigated the relationship between trace elements and vitamins with depressive disorders. The participants were examined on Cu, Zn, Ni, Cr, Mn, Mg, and Al serum levels (determined by atomic absorption spectrometry) and vitamin (E & A) concentrations (using high-performance liquid chromatography). Cu, Cr, and Al readings were found to be significantly higher in MDD patients than control, while the levels of Zn, Ni, Mn, Mg, vitamin E, and vitamin A were significantly lower in individuals diagnosed with depression. Finally, the ratio of Cu/Zn was high among depressed patients, which may have an important role in diagnosing and monitoring MDD. The results also suggest that disturbances in the level of trace elements and vitamins (E and A) are significantly related with MDD, studying Cu and Zn may be crucial in accumulating knowledge on the pathogenesis of depressive disorders, and that vitamin E deficiency may heighten the risk of developing MDD. Apparently, further exploration into trace element supplementation is required. [NPID: micronutrients, nutritional supplements, depression, Cu, Zn, Ni, Cr, Mn, Mg, Al, vitamin E, vitamin A, MDD, major depressive disorder]
Year: 2019
