Efficacy of probiotics on anxiety-A meta-analysis of randomized controlled trials

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Probiotics reduce negative mood over time: the value of daily self-reports in detecting effects

Growing interest in the microbiome–gut–brain axis has led researchers to explore how gut bacteria influence emotional well-being. Probiotics have emerged as a promising area for microbiome-based interventions in mental health; however, previous studies have yielded inconsistent results, particularly in healthy individuals. In a randomized, double-blind, placebo-controlled study by Johnson & Steenbergen (2025) involving 88 healthy […]

Effects of a psychobiotic supplement on serum brain-derived neurotrophic factor levels in depressive patients: A post hoc analysis of a randomized clinical trial

Since the gut microbiota was suggested to interact with brain-derived neurotrophic factor (BDNF), which has been associated with having antidepressant qualities in the past, this 2020 double-blind, randomized controlled trial aimed to elucidate the mechanism of action of a psychobiotic combination (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175; CEREBIOME) that has already significantly improved depressive […]