Diet-induced hypothalamic dysfunction and metabolic disease, and the therapeutic potential of polyphenols

This 2019 review summarizes the influence that polyphenols can have on the neural inflammation and mitochondrial dysfunction aspects of diet-induced hypothalamic dysfunction. Polyphenols were seen to help reduce oxidative stress and inflammation within the hypothalamus, enhancing leptin signaling and mitochondrial biogenesis in the process. The role of polyphenols in reducing the production of reactive oxygen species and in augmenting the natural oxidative defense systems also assists the prevention of neurodegeneration. Samodien et al. (2019) appreciate polyphenols as nutraceuticals with excellent potential as they have shown protective qualities against hypothalamic inflammation, mitochondrial dysfunction, and neurodegeneration. As hypothalamic inflammation spreads as an individual ages, polyphenol’s ability to possibly increase longevity should be studied, along with its therapeutic value in the management of mental health disorders since they are characterized too by advanced neuroinflammation. [NPID: micronutrients, nutritional supplements, polyphenols, neural inflammation, mitochondria, hypothalamic dysfunction, hypothalamus, oxidative stress, neurodegeneration, nutraceuticals, neuroinflammation, inflammation]

Year: 2019

Reference: Samodien, E., Johnson, R., Pheiffer, C., Mabasa, L., Erasmus, M., Louw, J., & Chellan, N. (2019). Diet-induced hypothalamic dysfunction and metabolic disease, and the therapeutic potential of polyphenols. Molecular metabolism, 27, 1–10. https://doi.org/10.1016/j.molmet.2019.06.022