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Depressed gut? The microbiota-diet-inflammation trialogue in depression
While the complex interaction of multiple mechanisms underlying depression still needs to be elucidated despite its high prevalence, this 2017 review provides a comprehensive overview of the multifaceted links between the microbiota, diet, and depression. In addition, Koopman & El AIdy (2017) summarized the existing literature on gut microbiota, inflammation and diet within the context of depression. Inflammation appeared to be linked with both biological factors such as excessive neurotransmitter concentrations as well as psychological processes such as adult stress reactivity and a history of childhood trauma, while a balanced microbiota community, modulated by diet, has been found to be a key modulator of host physiology. This review describes several pathways relating early life trauma, pharmacological treatment effects, and nutrition to the microbiome in depression, hopefully fostering novel interventions targeting the microbiota and aiming to treat depressed patients. [NPID: microbiome, MGBA, gut-brain axis, gut microbiome, depression, inflammation, stress, childhood trauma]
Year: 2017
