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A bioavailable form of curcumin, in combination with vitamin-D- and omega-3-enriched diet, modifies disease onset and outcomes in a murine model of collagen-induced arthritis
In this 2021 animal study, male DBA/1J mice were given a diet high in vitamin D3 (D3), and omega-3-fatty acids (O3FA) along with a highly bioavailable form of curcumin in a collagen-induced arthritis (CIA) murine model. The mice were challenged with bovine collagen II (CII) to induce arthritis. Joint thickness and standardized clinical score were checked regularly to determine the progress of disease in terms of severity. Hemshekhar et al. observed significantly drops in disease severity from curcumin administration alone (around 60%), while the mice eating the enriched diet plus curcumin supplements showed decreased disease severity by > 80% and maximally delayed disease onset and progression. It appeared that curcumin alone was responsible for mediating the suppression of anti-collagen antibodies and decreasing cellular infiltration and MMP abundance in the joints of the collagen-induced arthritis mice. But the daily curcumin supplementation in addition to the vitamin D3 and omega-3-fatty acids- enriched diet resulted in significantly more suppression of inflammatory biomarkers known to be associated with rheumatoid arthritis pathogenesis such as TNF, IFN-γ, and MCP-1. Since the combination of curcumin, vitamin D3 and omega-3-fatty acids have demonstrated their efficacy in delaying CIA severity and development in this animal model, it may be worthwhile assessing the use of these supplements in people at risk of developing rheumatoid arthritis in the future. [NPID: pain, vitamin D3, omega-3s, curcumin, animal, bovine collagen, joints, collagen, rheumatoid arthritis]
Year: 2021
