CNS anti-depressant, anxiolytic and analgesic effects of ganoderma applanatum (mushroom) along with ligand-receptor binding screening provide new insights: Multi- disciplinary approaches

The aim of this 2021 study was to test the CNS depressant, anxiolytic, and analgesic action of Ganoderma applanatum, a medicinal mushroom used in several health disorders. Two extracts of G. applanatum were prepared by dissolving in distilled water or ethanol. These G. applanatum extracts were named AEGA (aqueous extract of G. applanatum) and EEGA (ethanol extract of G. applanatum). The open field method, rotarod method, tail suspension method, and hole cross method were used to analyze whether AEGA or EEGA can slow down brain activity (central nervous system depressant effect). At both 200 and 400 milligrams per kilogram, AEGA and EEGA showed significant CNS depressant effects against all 4 tests used for CNS depressant activity. The elevated plus-maze test and hole board method revealed anxiolytic potential, while the acetic acid-induced writhing test, hot plate method, and tail immersion test were employed to examine analgesic action. Both doses of AEGA and EEGA demonstrated analgesic potential and anxiolytic ability. It can be concluded that AEGA and EEGA (2 extracts of G. applanatum) may act as CNS depressants, anxiolytics, and analgesics. [NPID: anxiety, analgesic, Ganoderma applanatum, mushroom, medicinal mushrooms, edible mushrooms, CNS depressant]

Year: 2021

Reference: Hossen, S. M., Islam, M. J., Hossain, M. R., Barua, A., Uddin, M. G., & Emon, N. U. (2021). CNS anti-depressant, anxiolytic and analgesic effects of ganoderma applanatum (mushroom) along with ligand-receptor binding screening provide new insights: Multi- disciplinary approaches. Biochemistry and Biophysics Reports, 27, 101062. https://doi.org/10.1016/j.bbrep.2021.101062