Association of total zinc, iron, copper and selenium intakes with depression in the US adults

Li et al. (2018) studied the relationship between the total consumptions of zinc, iron, copper and selenium, with depression. This cross-sectional study extracted the data of 14,834 adults (18+ years, 7399 male: 7435 female) from the National Health and Nutrition Examination Survey (NHANES) 2009-2014. In unadjusted model and age- and gender-adjusted models, total zinc, iron, copper and selenium intakes were inversely associated with depression; when the highest quartile of copper and selenium intakes were compared to the lowest quartile, the multivariate adjusted odds ratios (ORs) of depression was recorded as 0.68 and 0.46, respectively. In addition, when quartile 3 for total zinc and iron consumption was compared to the lowest quartile, the inverse associations of depression were statistically significant, with OR of 0.7 for zinc and 0.66 for iron. Furthermore, those adults who met the Recommended Dietary Allowances (RDAs) for zinc (OR: 0.74), copper (OR: 0.68) and selenium (OR: 0.52) had significantly lower odds of depression, compared to those below the RDA. These results suggest inverse associations between total zinc, iron, copper and selenium intakes with depression. [NPID: micronutrients, zinc, iron, copper, selenium, depression]

Year: 2018

Reference: Li, Z., Wang, W., Xin, X., Song, X., & Zhang, D. (2018). Association of total zinc, iron, copper and selenium intakes with depression in the US adults. Journal of affective disorders, 228, 68–74. https://doi.org/10.1016/j.jad.2017.12.004

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