Association between depression, anxiety symptoms and gut microbiota in Chinese elderly with functional constipation

Serotonin is a vital neurotransmitter that influences numerous physiological, neurological, and behavioral functions. Peripheral serotonin, mainly produced in the gastrointestinal tract, regulates motility and vascular tone, while central serotonin, synthesized in the brain, governs food intake, emotional regulation, memory, learning, and sexual behavior. Chronic high-fat diet (HFD) consumption has been shown to disrupt serotonin signaling […]

Major depressive disorder (MDD), being a complicated condition in nature, affects 280 million individuals globally and is a primary cause of disability. Numerous environmental variables, including medicines, nutrition, and microorganisms, have a role in the pathophysiology of depression disorders. The host immune system, genetics, and epigenetics are some of the contributors to the intricate underlying […]