Antidepressant-like effects of penta-acetyl geniposide in chronic unpredictable mild stress-induced depression rat model: Involvement of inhibiting neuroinflammation in prefrontal cortex and regulating hypothalamic-pituitaryadrenal axis (animal)

Cai et al. (2020) report their findings on the antidepressant-like effects of penta-acetyl geniposide ((Ac)5GP, a derivative of geniposide (a major active component of Gardenia jasminoides Ellis). While the rats were under chronic unpredictable mild stress (CUMS), (Ac)5GP treatment seemed to alleviate the depression-like behaviors induced by CUMS. Moreover, the elevations in interleukins (IL-1β, IL-6) and tumor necrosis factor (TNF-α) mRNA normally observed in chronic unpredictable mild stress were reversed by the (Ac)5GP. It was therefore thought that (Ac)5GP treatment improved the depression-like behaviors in rats possibly by inhibiting neuroinflammation in certain areas of the brain (prefrontal cortex) and blocking activations of proteins (NF-κB and NLRP3).
[NPID: antidepressant, herbs, stress, HPA, NF-κB, neuroinflammation]

Year: 2020

Reference: Cai, L., Mu, Y. R., Liu, M. M., Tang, W. J., & Li, R. (2020). Antidepressant-like effects of penta-acetyl geniposide in chronic unpredictable mild stress-induced depression rat model: Involvement of inhibiting neuroinflammation in prefrontal cortex and regulating hypothalamic-pituitaryadrenal axis. International immunopharmacology, 80, 106182. https://doi.org/10.1016/j.intimp.2019.106182