A novel anti-inflammatory role of Omega-3 PUFAs in prevention and treatment of atherosclerosis and vascular cognitive impairment and dementia

Simonetto et al. (2019) describes the link between atherosclerosis, vascular cognitive impairment and dementia (VCID) and inflammation, and explains why omega-3 polyunsaturated fatty acid (PUFA) supplementation may be useful to prevent and treat inflammatory-related diseases. Simonetto and her team (2019) state that the relationship between atherosclerosis and VCID has already been established, with risk of VCID increased by induction of cerebral infarction, or through systemic or local inflammatory factors that underlie both atherosclerosis and cognition. It was also highlighted that omega-3 PUFAs exert anti-inflammatory properties and decrease production of pro-inflammatory eicosanoids, which explains why supplementation of these fatty acids resulted in lower risks of different phenotypes of atherosclerosis and cardiovascular disease in experimental studies and clinical trials. [NPIDs: aging, elderly, cognitive decline, neurodegenerative disorders, dementia, cognition, vascular cognitive impairment, omega-3s, PUFAs, VCIS, cerebral infarction, inflammation, atherosclerosis]

Year: 2019

Reference: Simonetto, M., Infante, M., Sacco, R. L., Rundek, T., & Della-Morte, D. (2019). A Novel Anti-Inflammatory Role of Omega-3 PUFAs in Prevention and Treatment of Atherosclerosis and Vascular Cognitive Impairment and Dementia. Nutrients, 11(10), 2279. https://doi.org/10.3390/nu11102279

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