Hippocampal-dependent learning and memory (HDLM) refers to the process of acquiring and retaining information that relies on the proper functioning of the hippocampus. This type of memory encompasses various cognitive tasks, such as spatial navigation and declarative memory (memories of facts and events). HDLM is essential for forming new memories and recalling past experiences, and any dysfunction in the hippocampus can lead to deficits in learning and memory processes.