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Encyclopedia of Nutritional Psychology

Functional Medicine

Evidence-informed definition Updated August 24, 2026 How to cite this entry

Functional Medicine is a systems-biology-based approach to clinical practice that seeks to identify and address the underlying causes of chronic disease by examining the dynamic interactions among a patient’s genetics, environment, lifestyle, and physiological systems. Developed by Jeffrey Bland in 1990 and advanced institutionally through the Institute for Functional Medicine (IFM), it uses an extended patient history, detailed timelines, and matrix-based assessment to map antecedents, triggers, and mediators of illness across domains such as digestion and absorption, immune and inflammatory balance, hormonal and neurotransmitter signaling, detoxification, energy production, and structural integrity. Interventions emphasize personalized nutrition, targeted supplementation, sleep, physical activity, stress modulation, and relational and environmental factors.

In nutritional psychology, Functional Medicine is relevant because it foregrounds diet, the gut microbiome, micronutrient status, inflammation, and lifestyle inputs as modifiable contributors to mood, cognition, and behavior. Practitioners come from a range of clinical backgrounds, and Functional Medicine is typically practiced alongside — rather than in place of — medical, psychiatric, or psychological care.

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Written by Ephi Lu
Reviewed by CNP Encyclopedia Editorial Board
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Encyclopedia of Nutritional Psychology. (2026). Functional Medicine. The Center for Nutritional Psychology.

https://www.nutritional-psychology.org/encyclopedia/functional-medicine/
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