The CNP Microbiota-Gut-Brain Axis (MGBA) & Mental Health Research Category consolidates research exploring the interconnected relationship between dietary intake, the microbiome, and the gut-brain axis. To view each original study on the open internet, click “Original.” To view the CNP-written abstract summary, click “CNP Summary.” While only some of the CNP-written abstract summaries are available below for free, all abstract summaries are available to CNP members through the CNP Library Membership.
Major depressive disorder (MDD), being a complicated condition in nature, affects 280 million individuals globally and is a primary cause of disability. Numerous environmental variables, including medicines, nutrition, and microorganisms, have a role in the pathophysiology of depression disorders. The host immune system, genetics, and epigenetics are some of the contributors to the intricate underlying causes of depression. Alterations to intestinal microbiota and their metabolites affect how people with depressive disorders respond to stress and behave in social situations by influencing immune cell maturation and brain neurogenesis, which is mediated by epigenetic changes. In this study, Nohesara et al. (2023) address the possible contributions of dysregulated gut permeability to the emergence of depressive illnesses through changes in metabolites generated from the gut microbiota that have epigenetic consequences. In addition, the authors discuss how changes in the makeup of the gut microbiota might lead to epigenetic changes that can cause depressive illnesses. Focus is shed on the potential benefits of microbiota-derived metabolites, such as probiotics, butyrate (which acts as an epigenetic modifier), polyphenols, medications (such as antibiotics, antipsychotics, and antidepressants), maternal diet, and fecal microbiota transplantation, in mitigating depressive-like behaviors through altering the epigenetic landscape. Lastly, the authors review the difficulties and potential solutions connected to current treatment techniques for depressive disorders via microbiome-related epigenetic changes.
A cross-sectional study observing the association of psychosocial stress and dietary intake with gut microbiota genera and alpha diversity among a young adult cohort of black and white women in Birmingham, Alabama
Fermented foods: Harnessing their potential to modulate The Microbiota-Gut-Brain Axis for mental health
CNP Research Summary can be found in the CNP Library Membership
The role of gut microbiota in anxiety, depression, and other mental disorders as well as the protective effects of dietary components
Microbiota-induced epigenetic alterations in depressive disorders are targets for nutritional and probiotic therapies
CNP Research Summary can be found in the CNP Library Membership
Infant saliva microbiome activity modulates nutritional impacts on neurodevelopment
Lactobacillus from the Altered Schaedler Flora maintain IFNγ homeostasis to promote behavioral stress resilience
Extra-virgin olive oil and the gut-brain axis: influence on gut microbiota, mucosal immunity, and cardiometabolic and cognitive health
Neuropsychiatric and neurological diseases in relation to the microbiota-gut-brain axis: From research to clinical care
CNP Research Summary can be found in the CNP Library Membership
Lipids, gut microbiota, and the complex relationship with Alzheimer’s Disease: A narrative review
Inulin-type fructans and 2'fucosyllactose alter both microbial composition and appear to alleviate stress-induced mood state in a working population compared to placebo (maltodextrin): the EFFICAD Trial, a randomized, controlled trial
CNP Research Summary can be found in the CNP Library Membership
Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia
Microbiota from Alzheimer’s patients induce deficits in cognition and hippocampal neurogenesis
CNP Research Summary can be found in the CNP Library Membership
Effects of Ramadan intermittent fasting on gut microbiome: Is the diet key?
Discrimination exposure impacts unhealthy processing of food cues: Crosstalk between the brain and gut
CNP Research Summary can be found in the CNP Library Membership
Steamed broccoli sprouts alleviate DSS-induced inflammation and retain gut microbial biogeography in mice
Exploring the effects of a Mediterranean Diet and weight loss on the gut microbiome and cognitive performance in older, African American obese adults: A post hoc analysis
CNP Research Summary can be found in the CNP Library Membership
Gut microbiome composition may be an indicator of preclinical Alzheimer's disease
Interplay of metabolome and gut microbiome in individuals with major depressive disorder vs control individuals
CNP Research Summary can be found in the CNP Library Membership
Dectin-1 signaling on colonic γδ T cells promotes psychosocial stress responses
The gut microbiome, mild cognitive impairment, and probiotics: A randomized clinical trial in middle-aged and older adults
CNP Research Summary can be found in the CNP Library Membership
Guts imbalance imbalances the brain: A review of gut microbiota association with neurological and psychiatric disorders
The microbiota composition drives personalized nutrition: Gut microbes as predictive biomarkers for the success of weight loss diets
CNP Research Summary can be found in the CNP Library Membership
Association between depression, anxiety symptoms and gut microbiota in Chinese elderly with functional constipation
CNP Research Summary can be found in the CNP Library Membership
The microbiome-gut-brain axis regulates social cognition & craving in young binge drinkers
Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat
CNP Research Summary can be found in the CNP Library Membership
The association between gut-health promoting diet and depression: A mediation analysis
Fecal Lcn-2 level is a sensitive biological indicator for gut dysbiosis and intestinal inflammation in multiple sclerosis
CNP Research Summary can be found in the CNP Library Membership
Gut microbiome-wide association study of depressive symptoms
The effect of nut consumption (tree nuts and peanuts) on the gut microbiota of humans: a systematic review
CNP Research Summary can be found in the CNP Library Membership
Gut microbiota suppress feeding induced by palatable foods
Anti-inflammatory and immunomodulatory effects of probiotics in gut inflammation: A door to the body
CNP Research Summary can be found in the CNP Library Membership
Relationship between sleep disorders and gut dysbiosis: What affects what?
Sociability in a non-captive macaque population is associated with beneficial gut bacteria
CNP Research Summary can be found in the CNP Library Membership
Feed your microbes to deal with stress: A psychobiotic diet impacts microbial stability and perceived stress in a healthy adult population
The impact of almonds and almond processing on gastrointestinal physiology, luminal microbiology and gastrointestinal symptoms: A randomized controlled trial and mastication study
CNP Research Summary can be found in the CNP Library Membership
Dietary magnesium deficiency alters gut microbiota and leads to depressive-like behaviour
CNP Research Summary can be found in the CNP Library Membership
Effects of microbiota imbalance in anxiety and eating disorders: Probiotics as novel therapeutic approaches
CNP Research Summary can be found in the CNP Library Membership
The effects of stress and diet on the "Brain-Gut" and "Gut-Brain" pathways in animal models of stress and depression
A systematic review of gut microbiota composition in observational studies of major depressive disorder, bipolar disorder and schizophrenia
CNP Research Summary can be found in the CNP Library Membership
The gut microbiome influences host diet selection behavior
Nutraceuticals and physical activity as antidepressants: The central role of the gut microbiota
CNP Research Summary can be found in the CNP Library Membership
A gut feeling: Microbiome-brain-immune interactions modulate social and affective behaviors
CNP Research Summary can be found in the CNP Library Membership
Gut microbiome composition and diversity are related to human personality traits
CNP Research Summary can be found in the CNP Library Membership
Trait energy and fatigue may be connected to gut bacteria among young physically active adults: An exploratory study
A systematic review of gut microbiota composition in observational studies of major depressive disorder, bipolar disorder and schizophrenia
CNP Research Summary can be found in the CNP Library Membership
Similarly in depression, nuances of gut microbiota: Evidences from a shotgun metagenomics sequencing study on major depressive disorder versus bipolar disorder with current major depressive episode patients
The role of the gut microbiota in the development and progression of major depressive and bipolar disorder
CNP Research Summary can be found in the CNP Library Membership
The HPA axis dysregulation in severe mental illness: Can we shift the blame to gut microbiota?
CNP Research Summary can be found in the CNP Library Membership
Gut microbiota in depression: A focus on ketamine
The gut microbiome and mental health: Implications for anxiety- and trauma-related disorders
CNP Research Summary can be found in the CNP Library Membership
Gut-microbiota-targeted diets modulate human immune status
The interaction between tea polyphenols and host intestinal microorganisms: An effective way to prevent psychiatric disorders
CNP Research Summary can be found in the CNP Library Membership
The role of the intestinal microbiota in the pathogenesis of host depression and mechanism of TPs relieving depression
CNP Research Summary can be found in the CNP Library Membership
A microbiome-driven approach to combating depression during the COVID-19 pandemic
CNP Research Summary can be found in the CNP Library Membership
Microbiota and sleep: Awakening the gut feeling
CNP Research Summary can be found in the CNP Library Membership
Gut microbiome composition associated with major depressive disorder and sleep quality
CNP Research Summary can be found in the CNP Library Membership
Gut microbiota variations in patients diagnosed with major depressive disorder-A systematic review
Gut microbiota dysbiosis in depressed women: The association of symptom severity and microbiota function
The effects of psychobiotics on the microbiota-gut-brain axis in early-life stress and neuropsychiatric disorders
CNP Research Summary can be found in the CNP Library Membership
From probiotics to psychobiotics - the gut-brain axis in psychiatric disorders
The relationship between the gut microbiome and neurodegenerative diseases
CNP Research Summary can be found in the CNP Library Membership
Diet and the microbiota-gut-brain axis: Sowing the seeds of good mental health
CNP Research Summary can be found in the CNP Library Membership
From probiotics to psychobiotics: Live beneficial bacteria which act on the brain-gut axis
From isoniazid to psychobiotics: The gut microbiome as a new antidepressant target
CNP Research Summary can be found in the CNP Library Membership
Is eating behavior manipulated by the gastrointestinal microbiota? Evolutionary pressures and potential mechanisms
Long-term dietary patterns are associated with pro-inflammatory and anti-inflammatory features of the gut microbiome
Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals
CNP Research Summary can be found in the CNP Library Membership
The impact of gut microbiota disorders on the blood-brain barrier
CNP Research Summary can be found in the CNP Library Membership
Diet and microbiota linked in health and disease
CNP Research Summary can be found in the CNP Library Membership
Introduction to the special focus issue on the impact of diet on gut microbiota composition and function and future opportunities for nutritional modulation of the gut microbiome to improve human health
CNP Research Summary can be found in the CNP Library Membership
Dietary effects on human gut microbiome diversity
CNP Research Summary can be found in the CNP Library Membership
Gut-microbiota-brain axis and its effect on neuropsychiatric disorders with suspected immune dysregulation
Fermented foods, the gut and mental health: A mechanistic overview with implications for depression and anxiety
The microbiota-gut-brain axis: neurobehavioral correlates, health and sociality
CNP Research Summary can be found in the CNP Library Membership
Influence of tryptophan and serotonin on mood and cognition with a possible role of the gut-brain axis
CNP Research Summary can be found in the CNP Library Membership
Associations among diet, the gastrointestinal microbiota, and negative emotional states in adults
Gut-brain psychology: Rethinking psychology from the microbiota–gut–brain axis
CNP Research Summary can be found in the CNP Library Membership
Targeting the microbiota, from irritable bowel syndrome to mood disorders: focus on probiotics and prebiotics
Measuring the brain-gut axis in psychological sciences: A necessary challenge
CNP Research Summary can be found in the CNP Library Membership
"I am I and my bacterial circumstances": Linking gut microbiome, neurodevelopment, and depression
CNP Research Summary can be found in the CNP Library Membership
The food-gut human axis: The effects of diet on gut microbiota and metabolome
Food components and dietary habits: Keys for a healthy gut microbiota composition
CNP Research Summary can be found in the CNP Library Membership
Relationship between the gut microbiome and brain function
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The possible mechanisms of the human microbiome in allergic diseases
Gut-brain axis biochemical signaling from the gastrointestinal tract to the central nervous system: Gut dysbiosis and altered brain function
CNP Research Summary can be found in the CNP Library Membership
Gutted! Unraveling the role of the microbiome in major depressive disorder
Nutritional modulation of immune and central nervous system homeostasis: the role of diet in development of neuroinflammation and neurological disease
CNP Research Summary can be found in the CNP Library Membership
The gut microbiome and mental health: What should we tell our patients?: le microbiote intestinal et la santé mentale : que devrions-nous dire à nos patients?
From gut dysbiosis to altered brain function and mental illness: Mechanisms and pathways
Towards microbiome-informed dietary recommendations for promoting metabolic and mental health: Opinion papers of the MyNewGut project
The microbiota-gut-brain axis in neuropsychiatric disorders: Pathophysiological mechanisms and novel treatments
CNP Research Summary can be found in the CNP Library Membership
Harnessing gut microbes for mental health: Getting from here to there
Seeing the wood for the trees: A new way to view the human intestinal microbiome and its connection with non-communicable disease
CNP Research Summary can be found in the CNP Library Membership
Can gut microbes play a role in mental disorders and their treatment?
CNP Research Summary can be found in the CNP Library Membership
Can microbiology affect psychiatry? A link between gut microbiota and psychiatric disorders
Mind-altering with the gut: Modulation of the gut-brain axis with probiotics
CNP Research Summary can be found in the CNP Library Membership
The gut-brain axis in the neuropsychological disease model of obesity: A classical movie revised by the emerging director "microbiome"
CNP Research Summary can be found in the CNP Library Membership
The importance of diet and gut health to the treatment and prevention of mental disorders
CNP Research Summary can be found in the CNP Library Membership
Effects of psychological, environmental and physical stressors on the gut microbiota
Exposure to a social stressor alters the structure of the intestinal microbiota: Implications for stressor-induced immunomodulation
CNP Research Summary can be found in the CNP Library Membership
Gut-microbiota-brain axis and its effect on neuropsychiatric disorders with suspected immune dysregulation
Microbiome and cognitive impairment: Can any diets influence learning processes in a positive way?
CNP Research Summary can be found in the CNP Library Membership
A psychology of the human brain-gut-microbiome axis
The role of the brain-gut-microbiota axis in psychology: The importance of considering gut microbiota in the development, perpetuation, and treatment of psychological disorders
Crosstalk between the gut microbiota and the brain: An update on neuroimaging findings
CNP Research Summary can be found in the CNP Library Membership
Association of loneliness and wisdom with gut microbial diversity and composition: An exploratory study
CNP Research Summary can be found in the CNP Library Membership
Perturbations in gut microbiota composition in psychiatric disorders: A review and meta-analysis
Microbiota-induced epigenetic alterations in depressive disorders are targets for nutritional and probiotic therapies